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Formation of BMP-4 Gradient in Frog Embryos

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Which of the following contribute to the formation of the BMP-4 concentration gradient in the frog embryo?

A. BMP-4 is produced in the ventral portion of the embryo.

B. Chordin is produced in the Spemann organizer.

C. Chordin inhibits BMP-4.

D. Xolloid is produced in the ventral portion of the embryo.

E. Xolloid degrades chordin.

AA only
BA, B, and D only
CA, B, and C only
DA, B, C, D, and E
EA, C, and E only
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